Prurigo pigmentosa is a rare skin condition of unknown cause, characterized by the sudden onset of erythematous papules that leave a reticulated hyperpigmentation when they heal. The condition has been associated with a strict ketogenic diet in case reports in the medical literature.
Prurigo pigmentosa 是一种罕见的炎症性皮肤病,1971 年由 Nagashima 等人首次描述。它主要影响东亚血统的年轻女性,但也可见于其他人群。临床表现为颈部、胸部和背部对称分布的凸起红色斑块或丘疹,常呈网状排列,病程呈波动性,愈合后可留下深色色素沉着。Prurigo pigmentosa 可能与代谢改变有关,例如近年来流行的生酮饮食所致的代谢紊乱。 Prurigo pigmentosa, also known as Nagashima disease or keto rash, is a rare inflammatory skin disease initially described by Nagashima et al in 1971. Prurigo pigmentosa typically, but not exclusively, affects young females of East Asian ethnicity, presenting as a symmetrical eruption of urticarial papules on the neck, chest, and back. The papular eruption typically coalesces into a reticulated pattern that repeatedly resolves and recurs, resulting in hyperpigmented skin of cosmetic concern. Prurigo pigmentosa can be triggered by metabolic derangements, including those secondary to ketogenic diets, which have experienced a rise in popularity in recent years.
Prurigo pigmentosa 是一种皮肤病,表现为突发的瘙痒性网状红斑,随后会留下色素沉着斑。近期研究显示,Prurigo pigmentosa 与生酮饮食存在关联。该病可发生于任何年龄和性别,但女性更常见。若恢复正常饮食或局部皮肤治疗效果不佳,医生可能会开具口服抗生素疗程,如 doxycycline(多西环素)或 minocycline(米诺环素),剂量为每次 100 毫克,每日两次,疗程 1–2 个月。 Prurigo pigmentosa is a skin condition causing sudden, itchy, red bumps in a net-like pattern followed by dark spots. Lately, some evidences were founded that Prurigo pigmentosa is associated with the ketogenic diet. It can affect people of different ages and genders, with a tendency to be more common in females. In cases where returning to a regular diet or using skin treatments doesn't fully help, doctors may prescribe a course of oral antibiotics like doxycycline or minocycline (100 mg twice daily for 1 to 2 months).